Most supplements are best stored in a dry environment and at room temperature. This is because the two biggest enemies of supplements are humidity and changes in temperature. Before the question of storing vitamins and supplements comes into play, it's important to figure out which ones you actually need to take in pill form. For example, these vitamins are not worth it and can even be dangerous.
Only after you've done your research and talked to your doctor should you buy and store the pills safely. For optimal potency, vitamins and other dietary supplements should be stored in a cool, dry place. A refrigerator is certainly cold, but it's also full of moisture, which can reduce the shelf life and effectiveness of vitamins. The exceptions to this rule are supplements whose packaging specifically recommends refrigeration.
Keep your medications and supplements out of reach, preferably in the highest cupboard in the house. In general, these places change temperature frequently and have more moisture, sunlight, and bacteria. Some supplements lose their effectiveness when exposed to light, for example, and must be stored in opaque or dark-colored containers. Environments that face frequent changes in temperature, sunlight and humidity can ruin your medications and supplements and cause them to lose value.
Interestingly, the two rooms in the house that are most commonly used to store supplements may not be the most ideal environments. Supplements that are stored elsewhere are prone to “deliquescence,” a process in which moisture and condensation cause water-soluble vitamins, such as B vitamins and vitamin C, to dissolve.